Cyclobenzaprine: MedlinePlus Drug Information
Please note that we are unable to provide general health information or advice about symptoms by email. For general health information or symptom advice, please call us at any time of the day or night. The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time. The side effects listed below are not experienced by everyone who takes this medication.
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The plasma half-life is 1 to 3 days, and the duration of action is 12 to 24 hours. Cyclobenzaprine is supplied as 10-mg tablets and has a recommended dose of 10 mg 3 times per day. A new, controlled-release formulation of the drug is now available and appears to have a more favorable side-effect profile when compared with the immediate-release formulation. The use of weed or marijuana while on Cyclobenzaprine treatment is another of the drugs that interact moderately with Cyclobenzaprine. Using both Cyclobenzaprine and weed together can have a wide range of adverse effects. It is advised not to use the two together as it can increase the risk of side effects such as confusion, trouble concentrating, dizziness, and drowsiness.
Cyclobenzaprine (Oral Route)
In a pharmacokinetic study of sixteen subjects with hepatic impairment (15 mild, 1 moderate per Child-Pugh score), both AUC and Cmax were approximately double the values seen in the healthy control group. Based on the findings, FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with the 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of FLEXERIL in subjects with moderate to severe impairment is not recommended. At oral doses of up to 10 times the human dose, cyclobenzaprine did not adversely affect the reproductive performance or fertility of male or female rats. Cyclobenzaprine did not demonstrate mutagenic activity in the male mouse at dose levels of up to 20 times the human dose.
The most common treatment (and the one most likely to be covered by insurance) is 28 days at an inpatient or residential rehab facility. The usual adult dose of cyclobenzaprine is 10mg 3 times a day, with a range of 20 mg to 40 mg a day (given in divided doses). Use of this medication is not recommended for periods longer than 2 or 3 weeks. Taking this drug with an MAOI or within 14 days of stopping an MAOI could increase your risk of serious side effects. To help avoid interactions, your doctor should manage all of your medications carefully.
Over 375 drugs are known to interact with Cyclobenzaprine, with over 77% of them being moderate. That said, over 20% of them are known to cause major drug interactions, while just a little over 1% of them cause minor drug interactions. Alcohol, for instance, moderately interacts when mixed with Flexeril, and the same goes with weed. On the other hand, Tramadol, among other medications, causes major drug interactions and must be avoided when on Cyclobenzaprine treatment. Some interactions may be dangerous and must be avoided, while some may have various moderate and minor side effects. Let’s take a look at some of the more commonly used medications or drugs and their known interactions with Flexeril.
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The dosage is based on your medical condition and response to treatment. This medication should only be used short-term (for 3 weeks or less) unless directed by your doctor. Cyclobenzaprine flexeril.live HCl relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to central nervous system disease.
What should I know about storage and disposal of this medication?
Cyclobenzaprine (Flexeril) is structurally similar to TCAs and, as such, demonstrates significant anticholinergic side effects. It differs from the TCA amitriptyline by only one double bond. It is generally used for musculoskeletal conditions, including fibromyalgia and low back pain.
- That said, over 20% of them are known to cause major drug interactions, while just a little over 1% of them cause minor drug interactions.
- For most patients, the recommended dose of Flexeril is 5 mg three times a day.
- Tell your doctor if you are pregnant or plan to become pregnant during treatment with Flexeril.
- It is structurally similar to the tricyclic antidepressants and adverse effects similar to those seen with the tricyclic antidepressants are therefore to be expected.
- Call your doctor or local poison control center if you think you’ve taken too much of this drug.
Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.
The combination of Cyclobenzaprine and alcohol, weed, or Ibuprofen may increase the risk of side effects, just not as much as Tramadol does. Before combining and taking any of them, one must assess the medical risks that come with them to ensure that necessary actions are taken as needed. Unless carefully evaluated and advised by a health professional, one should not mix and use Cyclobenzaprine and Tramadol together.
If you or a loved one has been prescribed Flexeril but are no longer using it as prescribed or you’re combining it with alcohol, it may be time to seek help. A number of treatment approaches are available to help treat Flexeril and alcohol addiction. Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.